BAL Lazio

Tag Archives

Endpoint primari multipli negli studi oncologici

Pubblicato il 8 Aprile 2021

Da una revisione sistematica pubblicata sullo European Journal of Cancer emerge che in oncologia l’adozione di endpoint primari multipli negli studi randomizzati di fase III è una pratica piuttosto comune, ma soltanto una minoranza delle sperimentazioni rispetta le raccomandazioni delle agenzie regolatorie rispetto agli endpoint primari multipli, la definizione di endpoint “co-primari” e la correzione […]

Continua

Accedi agli articoli

Fakir AMS et al. Pandemic catch-22: the role of mobility restrictions and institutional inequalities in halting the spread of COVID-19. PLOS ONE 2021; 16(6): e0253348.

Alemany S, Avella-García C, Liew Z, et al. Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis in six European population-based cohorts. Eur J Epidemiol (2021). https://doi.org/10.1007/s10654-021-00754-4

Salazar de Pablo G et al. Universal and selective interventions to prevent poor mental health outcomes in young people: systematic review and meta-analysis. Harvard Review of Psychiatry 2021;29 (3) 196-215.

Currie JM et al. Prescribing of opioid analgesics and buprenorphine for opioid use disorder during the covid-19 pandemic. JAMA Netw Open 2021;4(4):e216147.

Marson A, Burnside G, Appleton R, et al.; SANAD II collaborators. The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. Lancet 2021;397(10282):1375-1386.

Marson A, Burnside G, Appleton R, et al.; SANAD II collaborators. The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. Lancet 2021;397(10282):1363-1374.

Zichi C et al. Adoption of multiple primary endpoints in phase III trials of systemic treatments in patients with advanced solid tumours. A systematic review. Eur j Canc 2021;149:49-60.

Seidler AN et al.; on behalf of the International Liaison Committee On Resuscitation Neonatal Life Support Task Force. Umbilical cord management for newborns <34 weeks' gestation: a meta-analysis. Pediatrics 2021; 147 (3) e20200576.

Gabrhelík R et al. Cannabis use during pregnancy and risk of adverse birth outcomes: a longitudinal cohort study. Eur Addict Res 2020. doi: 10.1159/000510821e

Una finestra sull’open access

  • BMC Family Practice
  • BMC Medical Education
  • BMC Nursing
  • BMJ Open
  • PLOS Medicine

Reset della password

Per favore inserisci la tua email. Riceverai una nuova password via email.