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Ipotiroidismo subclinico: meglio far finta di niente

Pubblicato il 3 Giugno 2019

Le nuove linee guida per la pratica clinica basate su una revisione sistematica pubblicata sul BMJ sono decisamente orientate (raccomandazione forte) contro l’uso routinario degli ormoni tiroidei negli adulti con ipotiroidismo subclinico. L’ipotiroidismo subclinico Dal punto di vista biochimico, l’ipotiroidismo subclinico consiste in livelli elevati di TSH con livelli normali di tiroxina libera. I pazienti […]

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Trattare o no con levotiroxina l’ipotiroidismo subclinico?

Pubblicato il 17 Maggio 2017

Uno studio europeo pubblicato sul New Engalnd Journal of Medicine cerca di fare chiarezza. Il trattamento farmacologico con levotiroxina in caso di ipotiroidismo subclinico, caratterizzato da un’elevata concentrazione sierica di TSH in presenza di normali valori di FT3 e FT4, è controverso. È stato condotto un trial randomizzato in doppio cieco controllato con placebo su […]

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Accedi agli articoli

Fakir AMS et al. Pandemic catch-22: the role of mobility restrictions and institutional inequalities in halting the spread of COVID-19. PLOS ONE 2021; 16(6): e0253348.

Alemany S, Avella-García C, Liew Z, et al. Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis in six European population-based cohorts. Eur J Epidemiol (2021). https://doi.org/10.1007/s10654-021-00754-4

Salazar de Pablo G et al. Universal and selective interventions to prevent poor mental health outcomes in young people: systematic review and meta-analysis. Harvard Review of Psychiatry 2021;29 (3) 196-215.

Currie JM et al. Prescribing of opioid analgesics and buprenorphine for opioid use disorder during the covid-19 pandemic. JAMA Netw Open 2021;4(4):e216147.

Marson A, Burnside G, Appleton R, et al.; SANAD II collaborators. The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. Lancet 2021;397(10282):1375-1386.

Marson A, Burnside G, Appleton R, et al.; SANAD II collaborators. The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. Lancet 2021;397(10282):1363-1374.

Zichi C et al. Adoption of multiple primary endpoints in phase III trials of systemic treatments in patients with advanced solid tumours. A systematic review. Eur j Canc 2021;149:49-60.

Seidler AN et al.; on behalf of the International Liaison Committee On Resuscitation Neonatal Life Support Task Force. Umbilical cord management for newborns <34 weeks' gestation: a meta-analysis. Pediatrics 2021; 147 (3) e20200576.

Gabrhelík R et al. Cannabis use during pregnancy and risk of adverse birth outcomes: a longitudinal cohort study. Eur Addict Res 2020. doi: 10.1159/000510821e

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